rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

Objectives: Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral Service Window Hardware and executive dysfunctions.We propose that neuromodulation based on rTMS will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and

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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis

Abstract Background IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biomarkers.This study is the first to assess methylati

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